Post-synaptically, where they strengthen rather than

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{"slip": { "id": 159, "advice": "What's stopping you?"}}

{"slip": { "id": 185, "advice": "You can fail at what you don't want. So you might as well take a chance on doing what you love."}}

{"type":"standard","title":"Metabotropic glutamate receptor 3","displaytitle":"Metabotropic glutamate receptor 3","namespace":{"id":0,"text":""},"wikibase_item":"Q6594119","titles":{"canonical":"Metabotropic_glutamate_receptor_3","normalized":"Metabotropic glutamate receptor 3","display":"Metabotropic glutamate receptor 3"},"pageid":14474523,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/1/1e/Protein_GRM3_PDB_2e4u.png/330px-Protein_GRM3_PDB_2e4u.png","width":320,"height":253},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/1/1e/Protein_GRM3_PDB_2e4u.png","width":938,"height":743},"lang":"en","dir":"ltr","revision":"1280568475","tid":"b05c6876-0179-11f0-b5a5-a984a1dedbc3","timestamp":"2025-03-15T08:44:21Z","description":"Mammalian protein found in humans","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Metabotropic_glutamate_receptor_3","revisions":"https://en.wikipedia.org/wiki/Metabotropic_glutamate_receptor_3?action=history","edit":"https://en.wikipedia.org/wiki/Metabotropic_glutamate_receptor_3?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Metabotropic_glutamate_receptor_3"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Metabotropic_glutamate_receptor_3","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Metabotropic_glutamate_receptor_3","edit":"https://en.m.wikipedia.org/wiki/Metabotropic_glutamate_receptor_3?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Metabotropic_glutamate_receptor_3"}},"extract":"Metabotropic glutamate receptor 3 (mGluR3) is an inhibitory Gi/G0-coupled G-protein coupled receptor (GPCR) generally localized to presynaptic sites of neurons in classical circuits. However, in higher cortical circuits in primates, mGluR3 are localized post-synaptically, where they strengthen rather than weaken synaptic connectivity. In humans, mGluR3 is encoded by the GRM3 gene. Deficits in mGluR3 signaling have been linked to impaired cognition in humans, and to increased risk of schizophrenia, consistent with their expanding role in cortical evolution.","extract_html":"

Metabotropic glutamate receptor 3 (mGluR3) is an inhibitory Gi/G0-coupled G-protein coupled receptor (GPCR) generally localized to presynaptic sites of neurons in classical circuits. However, in higher cortical circuits in primates, mGluR3 are localized post-synaptically, where they strengthen rather than weaken synaptic connectivity. In humans, mGluR3 is encoded by the GRM3 gene. Deficits in mGluR3 signaling have been linked to impaired cognition in humans, and to increased risk of schizophrenia, consistent with their expanding role in cortical evolution.

"}

{"fact":"When a cats rubs up against you, the cat is marking you with it's scent claiming ownership.","length":91}

{"fact":"Researchers are unsure exactly how a cat purrs. Most veterinarians believe that a cat purrs by vibrating vocal folds deep in the throat. To do this, a muscle in the larynx opens and closes the air passage about 25 times per second.","length":231}

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{"fact":"A happy cat holds her tail high and steady.","length":43}